We are pleased to share that our latest in vitro study on Genefill DX has just been published and is publicly available.

This research probes beneath the surface to reveal how the filler truly performs, offering science‑backed evidence of its three-fold action: deep hydration, structural volumization, and visible skin rejuvenation.

For aesthetic professionals, clinics, and anyone committed to high-quality outcomes, these findings deepen confidence in what Genefill DX delivers. It also sheds light on why it remains a leading choice in advanced facial treatments.

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What the Study Explores and Why It’s Important

This publication marks one of the most detailed lab-based explorations of Genefill DX we have done. It sheds light not only on its visible effects like hydration and lift, but also on how it supports deeper layers of the skin through biostimulation.

Using advanced in vitro testing, the study evaluated:

• The filler’s physicochemical and rheological characteristics
• Its influence on fibroblast activity, moisture retention, and tissue behavior
• Collagen (types I, III, IV, and VI) and production
• Comparisons with other commonly used filler categories, including HA, HA+CaHA, CaHA, and PLLA

For those seeking to make well-informed decisions or enhance treatment planning when it comes to using biostimulatory injectables, this data provides valuable context that bridges science and real-world outcomes.

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Key Study Highlights: What Sets It Apart

The study highlights what sets Genefill DX apart from traditional fillers. It has a unique hybrid formula that combines cross-linked hyaluronic acid with dextranomer microspheres for its triple-action effects. Other than just adding volume, it also works on multiple levels to refresh, hydrate, and visibly enhance the skin.

Here are some of the most compelling takeaways:

• Faster recovery response: In lab conditions, tissue repair progressed 2-3 times faster compared to CaHA fillers.
• Comprehensive collagen support: Production of collagen types I, III, IV, and VI, as well as elastin, was significantly boosted. This leads to smoother, firmer-looking skin.
• Long-lasting hydration: Genefill DX delivered immediate moisturization that stayed consistent, helping the skin remain supple and fresh.
• Balanced biological response: Cytokine activity suggested a skin-friendly environment, supporting both comfort and visible skin health.
• Natural-looking movement: Thanks to its ideal viscoelastic properties, the filler can blend seamlessly with facial expressions. No stiffness, just smooth integration.

Together, these findings reinforce Genefill DX as a true next-generation filler. Designed not only for volume, but for lasting skin quality and natural elegance.

Where Science Meets Natural Rejuvenation

Genefill DX stands out for its unique triple-action approach that delivers deep hydration, refined volume, and visible rejuvenation, all in one formulation. It’s designed for those who don’t just want beautiful but temporary results, but those who value subtle, long-lasting enhancements that work in harmony with their natural features.

By improving skin texture and elasticity while preserving natural facial movement, this filler supports the modern aesthetic ideal: results that feel as good as they look. It aligns with the shift toward personalized care, early intervention, and a more holistic, natural-looking approach to aging.

For aesthetic providers, this means having a filler that delivers volume and supports real skin quality improvements backed by scientific data.

For patients, it offers confidence in a product designed to work in harmony with your skin, one that provides results that look natural, feel seamless, and last longer.

How to Access the Study

The full article is available for you to read here – https://link.springer.com/article/10.1007/s00266-025-05245-5 

Ortiz-Flores RM, Escamilla-Sanchez A, Cidoncha-Morcillo B, Mastronardi L, Fontenete S, Garcia-Delgado R. Enhanced Facial Rejuvenation: Biostimulatory Effects of Hylan Gel Dermal Filler DX on Collagen Synthesis and Tissue Regeneration. Aesthetic Plast Surg. 2025 Oct 13.

Want to Learn More About Genefill DX?

If you're curious about the science behind Genefill DX or how it can elevate your approach to facial rejuvenation, we're here to help. Whether you’d like access to the full study or want to explore what makes this filler different, we’re just a message away.

Contact us and get started with your facial rejuvenation journey today!